Viewing profile — alexholehouse

This is one in a number of papers exploring how biological phase separation/condensation may have provided favourable microenvironments for early life development. For a nice prime…

Right - yeah; I don't know, I had the same thought when I read the commentary (I read the paper first). Nothing in the papers suggests the ability to monitor formation/loss in real…

Yeah agreed (what in vitro means to different people is a whole other conversation :-P), but that sentence makes it pretty clear that by in vitro they mean not in cells (because it…

So it seems like there are two timescales for what 'transient' means in the paper. 1) There are different levels/numbers of i-motifs identified depending on the cell cycle position…

But this is literally the entire point of the this paper. The sentence you just pasted was the the previous state of the art, this paper makes the point that they have now imaged t…

>My take on the not-listening thing -- of course I'm not Aron -- is that if you've heard a faction hector you a lot, and you don't think they're listening to you except maybe to ma…

Ha! - point extremely well taken, in much the same vein as "I'm not racist, BUT...". I did feel awkward writing it - in this case it was actually meant sincerely. I really wasn't s…

Then, with all due respect (and perhaps I misunderstood), perhaps you should consider a greater degree of open mindedness? If the fact that you disagrees with the first clause in a…

As mentioned in the memo, gendered interests are predicted by exposure to prenatal testosterone – higher levels are associated with a preference for mechanically interesting things…

So for some context, my work is not directly about evolution, but about how amino acid sequence determines function in the context of unfolded/disordered proteins. That said, here …

Not at all - there's some additional text that provides set-up for the idea of mechanism. Re-reading it now cold, I read it exactly as you (and others) did as well. And I (embarras…

The thesis won't be publicly available for a while because there is fair amount of (currently) unpublished data that is associated with various collaborations.

Thank you - categories vs. categorise is a great spot!!! Where are the spelling mistakes? I don't see the missing 'the' in the first sentence? Mechanism here is in the abstract, if…

This is oddly poignant to me. I just (literally a few hours ago) submitted my PhD thesis on (broadly) the biophysics of emergent phenomena. People don't usually read theses cover t…

Many of these proteins are intrinsically disordered proteins (IDPs), meaning they don't actually have a set 3D structure, but instead existing in a kind of 'cloud' (ensemble) of in…

Great to see this in the NYT. I'm working with Thomas (who, in addition to being a truly exceptional scientists is a really great guy) on understanding the underlying biophysics of…

One thought: FitBit's customer service with me has been nothing but exceptional from start to finish, and is the reason I have bought several for family members. I would hope that …

Short chain fatty acids can be things like acetic acid, propionic acid, butyric acid. The fermentation process takes in fiber and puts out these guys, so while fiber isn't an SCFA …

Nothing, because I literally don't have an account.

So, interestingly, it had me logged in to reddit, but I don't actually have a reddit account at all. Thoughts?

I wrote up the course a few years ago for easy reference. I need to update these notes it as I have about a year's worth of (minor) typos that people have pointed out [which is hug…