Viewing profile — JunkDNA

I have fond memories of playing the original Falcon on my Amiga 500. It felt like magic after years of playing F15 Strike Eagle on the Apple IIc. Hearing real sound effects kicking…

This article isn’t particularly helpful. It focuses on a ton of specific OpenAI business decisions that aren’t necessarily generalizable to the rest of the industry. OpenAI itself …

I keep seeing this charge that AI companies have an “Uber problem” meaning the business is heavily subsidized by VC. Is there any analysis that has been done that explains how this…

Exactly. If you are an L7 and making an average L7 salary, nobody should have to squint and tie themselves in knots to figure out the connection between your contribution and your …

They’re not using mRNA. They are using a viral vector that contains DNA.

I’m not sure if it’s a false memory or not but I believe there was a pretty cool demo that used this as the background music as well.

Bingo. I wish I could upvote this comment more. All the geeks get distracted by words like “cloud” or “virtual” and forget that all this stuff we depend on has a physical presence …

I highly recommend the piece by Derek Lowe down thread, but the tldr is basically that researchers have believed amyloid plaques cause the symptoms of Alzheimer's and so the theory…

I was on one of the teams that refuted the claims of horizontal gene transfer in the original human genome paper. The bar for establishing a true case of horizontal transfer in ver…

In business, many times the lack of any decision (good or bad) wastes valuable time. Especially for leaders, unblocking teams to move forward has real value beyond whether or not t…

USB remains the only connector I use where I routinely get the orientation wrong 3 times.

It’s not a vaccine if you don’t have efficacy data. You can go snort all kinds of peptides all day long, that doesn’t mean you’re going to actually have something useful happen. Do…

Speculation on the other thread is too many people have flagged the other post.

My daughter now 10 was diagnosed with a severe egg allergy around the time she turned 1. We aren't vegans and I love all kinds of things with egg (including home made pasta). We tr…

I would argue what makes the world a better place is ensuring companies have to innovate on their own. That’s what leads to breakthroughs and new things. Constraints often breed in…

There is sometimes specific information about the actual manufacturing process or synthesis that companies provide. Given that this is an entirely new vaccine technology that has n…

It was a murky situation, but LYMErix comes to mind: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/

Syapse here! We are a real-world data company working across life science (pharma), hospitals, and with the FDA. We want to use real-world evidence to improve the outcomes of cance…

It didn't come across in my post in retrospect, but just want to say clearly I love this idea and the ambitious nature of it. I think when someone works in drug discovery, it's har…

A few random thoughts I'm curious about (full disclosure: I worked in anti-infectives R&D as a bioinformatician early in my career for a major pharma) 1) One big challenge in synth…

I'm glad you posted this because when I saw the headline to this article my first reaction was, "Wait, this isn't news to me, I fired a ton of these things in that video game". The…

Spending more on marketing than R&D has been a favorite thing to zero in on but it's not really a useful metric. See here: https://blogs.sciencemag.org/pipeline/archives/2013/05/23…

There is a fundamental difference between a CEO at company operating at GSK's scale and for example, a few hundred person startup biotech. It's a mistake that engineers and domain …

Have you ever been in an executive leadership position that required you to make tough decisions? As someone who recently has entered this realm, let me tell you: most of the decis…

Back in the late 90’s and early 00’s, there were a ton of cpu platforms around: SGI MIPS, DEC Alpha’s, Intel, Sun SPARC, etc... while I will admit it was a colossal pain working so…