Viewing profile — HedonicEscal8r

If the kid's old enough to be hiding their internet history from their parents, they're old enough to have some privacy.

Not that I recommend being on 3-MMC at work, but it's just a matter of dosage. People take pharmaceutical doses of Adderall at work and 10x higher recreational doses at clubs.

The only common drugs that cause deadly withdrawals are alcohol and benzodiazepines. Opioid withdrawals are famously extremely unpleasant but not typically considered life-threaten…

"In experimental studies, the incidence of headache was 50% and the incidence of clinically significant distress or functional impairment was 13%." That is by definition not what "…

> Mentioning that they can't actually get pregnant, or impregnate someone, is taboo. Don't know the context, but I don't think this is a "trans" thing. It is usually considered tab…

I agree that you should almost never offer amputations for BIID in minors, since delaying until adulthood would only risk a couple of years of distress and would not cause addition…

If you think that a modal person who transitions does so because they don't understand what biological changes can be achieved* and/or because society doesn't accept them "as they …

I disagree with this, puberty blockers should be used sparingly and certainly should not be taken until adulthood. Can you imagine starting puberty at 18? Trans children deserve to…

If you are 11 and wait 7 years to get a tattoo, your tattoo will look just as good or better. If you are 11 and wait 7 years to transition, you will suffer irreversible physical an…

> It’s literally irreversible damage when you mess up with hormones while on puberty. This is equally true when you don't intervene. The children being recruited for this study wou…

I think this is a failure of empathy. "Being unable to transition before a certain age" in this context entails a child having their body modified against their will, which they ca…

Which is also wrong. People living with BIID are (usually) not irrational. The small percentage that do seek amputation have usually exhausted all treatment options, and find that …

Yes, tanning is downstream of the activity of the p53 tumor suppressor protein in response to UVB-induced damage: https://www.lesswrong.com/posts/EFiCGc3YwadZBzvZ3/contra-byr...

Surely you would not be confused by "Place the word Madagascar in a way that makes no sense."

1. While it's difficult to put a number on exactly what % of the time this is true, depression is not always, and I would say not often, a situational problem. For almost every dep…

Yup, and IP theft is morally good. Are we not on HackerNews?

I agree, sounds suspicious and likely misremembered.

She had Snijders Blok-Campeau syndrome, which is caused by mutations in the CHD3 protein, which manages the structure of DNA. In her case, it was this missense variant: https://www…

> May be such infusion would really serve as a vaccine prepping the immune system for the main infusion later? This is correct and exactly the problem. You don't want the immune sy…

Malignant hyperthermia?

There are many children with life-threatening rare diseases that would be much better candidates for risky experimental treatment like this. Very sad case.

Fidji Simo didn't disclose what condition she suffers from. In 2025, she co-founded ChronicleBio, which aims to accelerate progress on POTS, ME/CFS, Long COVID, and other neuroimmu…

I know someone who knew such a women that benefited from this suggestion, so for what it's worth: women who feel strongly about having kids but are struggling to find a suitable pa…

By the 23rd century, sexual reproduction will be vastly transformed by technology. The discussions we're having now will be unrecognizable.