Viewing profile — Gatsky

Read the ESR1 rapid update. The methods say: "A targeted electronic literature search was conducted to identify any additional phase III randomized controlled trials in this patien…

Sorry to hear you have suffered poor quality interactions with doctors. Being honest, if there is no trust in the relationship between patient and doctor, then nothing else matters…

Actually doctors would be universally happy to get more help and support to deliver better healthcare. That you don't talk about that is quite telling, or is that what you mean by …

I don't think it is false. I can only speak of my experience as an oncology healthcare provider. I spend many hours each week digesting the literature, and https://old-prod.asco.or…

The president of Medicens sans frontieres, Rowan Gillies, gave a speech once. He had a drawing of a patient and the doctor inside a circle. His comment was 'Other people keep tryin…

Well you discount the most important thing in the first line. 'Cutting-edge' is a funny way of saying 'most effective', as if it were somehow irrelevant. I didn't say most evidence…

Disagree. I change practice on Monday after a single quality trial. Pick up any society guideline, only a small amount of the recommendations rely on meta-analyses. Look at immunot…

Yeah, well in my field, oncology, meta-analyses are somewhat irrelevant. As you can imagine, the bar for completing a phase 3 randomised trial in oncology is pretty high. Meta-anal…

IRBs do not evaluate the value of a research endeavour. They are in fact unable to do this due to lack of knowledge and expertise. They approve trials which fit the mold of trials …

The biggest issue, IMHO, is that clinical trials are often unethical. This is both in theory and especially in practice. I say this as a physician and clinical trial investigator. …

Some people aren't worth it. Some people are just miserable. Not depressed, just miserable. Some people are insecure, vindictive, manipulative, querulous, disagreeable. Having a re…

Antivirals probably won’t help as most infections are silent, a vaccine is needed. Moderna is working on one.

I think this is a great comment, with much broader implications for living well. Unmooring the sense of self from external factors is one important aspect of spirituality.

This reference [1] tends to support what you are saying: > For this thesis, an atmospheric propagation code named ANCHOR (Atmospheric NPS Code for High Energy Laser Optical pRopaga…

There are thousands of sequenced human genomes available to access for research purposes (1000 genomes project, UK biobank etc) so one additional genome adds no marginal value.

Re WGS there are a lot of well established tool chains that are FLOSS (eg https://github.com/bcbio/bcbio-nextgen ). You could run alignment and variant calling on a beefy workstati…

Such as? I’ve worked in genomics labs, they would be quite happy to delete stuff.

Yes, find a local sequencing provider and arrange to do a SNP chip or whole genome sequencing. In the contract ask that they delete your data after delivering it to you. This will …

> Viewers will be able to "order up" films—for example, "I want a film about a panda and a unicorn who save the world in a rocket ship. And put Bill Murray in it." > From there I b…

Although quite uncharitable, I can believe this has some truth to it. She underwent a visible transformation for the trial, wearing her hair down and changing her entire mien. Quit…

I feel that alignment is not just hard but impossible, at least if you want something truly useful. Maybe the only thing you can do is let an AI develop and observe its nature from…

Reading this makes you realise how much of what makes Seinfeld good is in the skillful delivery. I wonder how much they would have to rehearse to get it spot on.

The NYT death announcements have this tone. It says at the bottom that a formal obituary will be forthcoming.

Very interesting. The increase in Coeliac disease will mostly be due to the advent of a useful blood test to detect it. The lack of association between other autoimmune diseases an…

Yeah this doesn’t quite sit right. It lacks any detail about what Google is actually doing.