Viewing profile — Ezku

An interesting piece featured in the article: “Concept and Location Neurons in the Human Brain Provide the ‘What’ and ‘Where’ in Memory Formation”, Nature Communications 2024 ( htt…

This book is probably about a very different kind of ”engineering” than what you had in mind, but it’s been highly influential to my thinking: “The Social Construction of Reality: …

Research citation & abstract, for other PDF-challenged individuals: Braddy, Jon. “Utilizing the Octothorpe (#).” Exchanges: The Interdisciplinary Research Journal, April 2022. http…

Your point is a very important one. Do we check the interactions of a tentative drug molecule against every single molecular target in the body, and do we track what happens as a r…

Is it really considered acceptable not to link to the scientific research you are basing your news on? Pubmed link (with abstract); full text is paywalled: > A neuro-metabolic acco…

From the comments here, I was expecting to find myself hopelessly out of date, and to end up with a migraine trying to parse through a mindnumbing list of changes. Turned out I was…

Perhaps not many in this audience are dealing with having to mitigate the prospect of dementia. How about something close to the horizon for almost all of us? > Vitamin D deficienc…

FWIW, I think the article agrees. > vitamin D effects were significantly greater in females versus males and in normal cognition versus mild cognitive impairment. > vitamin D effec…

Peripheral and central serotonergic systems are both relevant: > Because 5-HT cannot cross the blood-brain barrier, the peripheral 5-HT system is functionally separate from the cen…

Well spotted! > This is a modification of IBM's Plex font. https://github.com/iaolo/iA-Fonts/tree/master/iA%20Writer%20...

Great information & a good summary, thank you! If I’m looking to get more in-depth with the known mechanisms of locus coeruleus and episodic memory, would you be able to recommend …

I do often share this sentiment, even if I’m not in agreement with your tone. But I’m curious — > Specific qualia have a higher cortical resonance, due to overarching reinforcement…

Oh, this was a new one for me. In case you like narrow but Victor’s not your thing, I can enthusiastically point you towards Iosevka. (That’s also available in Victor’s comparison …

I’m thinking your reference to composing red functions doesn’t seem congruent with your desire to discuss algebraic effects. Composing arbitrarily many red functions, or blue funct…

> the compact camera market is dying. > Olympus just sold off their camera division. And someone _bought_ that camera division. With the intent to continue designing, manufacturing…

The paper explicitly states that it’s about Functional Relational Programming, so that’s verifiably correct. I’m not sure if I can agree, though. > It actually doesnt have much to …

The author seems to be referencing a project of theirs with a Finnish name, so perhaps my intuition as a native Finnish speaker can help. In Finnish you’d likely pronounce pijul [p…

My personal take is that io-ts _is_ typescript’s aeson, but if you’re scared of the baggage it comes with then how about giving zod a try? https://github.com/vriad/zod

I have a hypothesis that this condition and ADHD are related. ADHD researcher Dr Russell Barkley links Vygotsky’s theories of childhood development to the mechanism by which ADHD i…

Thanks for the reply. So, careful application of mapped types and removing the ability to type a property as `foo: bar | undefined`. I understand this is desirable a lot of times e…

Very strongly agreeing with this assessment and hoping Colin will come to agree. A zero-argument function is either a constant, or a side-effect. Given we don’t want a side-effect,…

You mention creating object types with optional keys is cumbersome in io-ts. How is that solved in zod, exactly? What allows you to map `foo: union([bar, undefined])` to `foo?: bar…

Thanks for pointing that out! I wonder why that is :S

Appears to have goals similar to https://parceljs.org/ , except parcel is under active maintenance and development whereas the latest release on this one is from a year ago. Am I m…

Anecdotally, both of these were difficult to get to run at all and offered subpar developer experience on macos. :(