Viewing profile — Duller-Finite

That describes a related but previous Nature paper from the same group, whereas this is referring to a more recent Science paper.

Yeah seems like related to homeopathic medicine (aromatherapy or essential oils or tinctures)

the study said that the 5 patients with VITT that they looked at had the IGLV3-21 * 02 polymorphism, but it's a fallacy to say that means that you can't get clotting without it

that study used TALENs; this one used CRISPR base editors

It's a shame that Perceptive Automata shut down.

Glp and G9a are ubiquitous as they are import epigenetic regulators (histone methyltransferases). Sounds difficult to work on, and hard to supplement if they play an important role…

TRP channels were first cloned over 20 years ago, and are indeed medically relevant for nociception and pain. The piezos are equally relevant; knockouts are embryonically lethal, a…

As an example, Douglas Bates, the author of R's lme4 excellent package for generalized linear mixed-effects models, has switched to julia to develop MixedModels.jl. The julia versi…

David Baker's group (author of the RoseTTAFold paper out today in science) has multiple exciting examples of de novo design of proteins. For example, see [1] or [2], and [2] was sp…

This paper is the first structure of any odorant receptor-ligand interaction. There's currently no equivalent structure for mammalian odorant receptors to validate the docking theo…

Not really. GPCRs amplify signals at each step via their second messenger cascade. These channels form homotetramers whose structure differs greatly from the canonical seven transm…

This is truly a landmark study. This is the first structure of any odorant receptor. It is, however, one from an insect, so the structure is not homologous to mammalian olfactory r…

The Code Breaker by Walter Isaacson is a recent biography of Jennifer Doudna, who won the Nobel Prize for her pioneering work on CRISPR, that you might enjoy

I don't follow. What's stunning about it? Doesn't it just mean that there is little evolutionary pressure or selection on the olfactory receptor genes? Not sure what the discovery …

RNA uses uracil/uridine rather than thymine, but uridine is actually quite immunogenic. That's what has prevented people from using mRNA as a therapy until recently, when the found…

lipofectamine is used for in vitro transfection, not in vivo gene delivery. The vaccines use lipid nanoparticles rather than liposomes

A similar article was published in Wired about a month ago: https://www.wired.co.uk/article/mrna-coronavirus-vaccine-pfi...

I have no idea why you think that there were no studies in April. A quick search shows that's wrong. There were initial reports in March, followed by many peer-reviewed studies tha…

Yes, there were a lot of reports back in March about the loss of smell as a frequent and specific symptom for COVID-19. I'm not sure why this article acts like it's a new thing. An…

There were many papers that came out over 4 months ago with more people and other approaches, all with similar conclusion [1-3]. Not sure why this paper is getting a lot of press. …

This is an interesting and well-done paper. It is, however, difficult to evaluate these mouse studies because, unlike human ACE2, mouse ACE2 doesn't facilitate SARS-CoV-2 cell entr…

While you're right they edited the embryos the sentence you quoted is describing a drug (680C91) that they bath-applied to inhibit the TDO enzyme (as a positive control), rather th…

The article reports on the in vitro results and says they're going to be doing further validation in vivo. As I mentioned before, the same has been true for basically every other a…

Normally I agree that press releases way oversell the research, but I don't think that was the case here. Their camelid nanobody approach seems to be a fairly novel idea with some …

That's why I'm in favor of this change in nomenclature.