Viewing profile — DavidSJ

> Worse than 0.01% of humans means that there are 8,000,000 people better than it. I know that's being pedantic I understand what you're saying. Since we're being pedantic, it mean…

I've been a regular reader of Alzforum, and cite multiple of their articles in the blog post that was linked up above. https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h.…

Perhaps I am just not well-informed but 30% slowdown in progression translates to sufferers have some mild improvement in cognitive tests and live a few months longer. A few years …

Note that not all AD-causing mutations in APP also cause amyloid accumulation, for example APP-Osaka (loss of APP residue E693) results in familial AD without any accumulation of a…

Yes, there is a clear sequence of how AD pathology develops, starting with amyloidopathy and progressing to tauopathy, but 1) there is as yet no established molecular connection be…

Thanks, great challenges. One may then ask, what is being remedied in the many, many, studies that claim to successfully target amyloid toxicity in mice? And is this relevant to th…

This is a reasonable challenge. I won't and shouldn't be able to convince you that my process was satisfactory, but I'll describe it anyways. I agree that I don't have the qualific…

I did. I started out very skeptical, then got convinced by the quality of the evidence.

That's fair. I responded to hostility with hostility. Perhaps I should have ignored the comment or just responded kindly despite the hostility.

The drug was discontinued later. You're thinking of aducanumab. Lecanemab and donanemab have been in widespread use for several years now, and open-label extensions vs. external co…

Those are amyloid-only mice. It's an amyloid+tau disease, with tau the proximate cause of neurodegeneration. Normal mice don't get tau pathology, whereas even healthy human beings …

Thanks for these comments! The multiple pathways into a common entrypoint is definitely a challenge to communicate.

You read the article in which I discuss the matter you say I was unfamiliar with?

Not reverse; the neurons have died. Cease, yes, if the cause is removed early enough. But if you intervene too late (once symptoms are detectable), then the downstream tau patholog…

The hypothesis that amyloid is simply a downstream effect, not a cause, is of course worth considering, and where my mind was at when I first approached the literature skeptically.…

Now if we consider amyloid beta therapies: we have treatments that target amyloid beta with varying degrees of success but at least some show definite reductions in amyloid beta pl…

As noted elsewhere in this thread, which you seem not to have read, I discuss that matter in the article, which you also seem not to have read.

What started as an argument to ignore arguments and evidence and instead rely on authority, seems now to have morphed into an argument that we should ignore the authority of the es…

You said the camp promoting the amyloid hypothesis has struggled greatly to come up with evidence to support its position. What did you mean by that if not a read of the quality of…

Is your view that amyloid is actually a minority view among researchers? That seems completely wrong based on basically every conference proceeding I've viewed and the volume of pa…

1. I don't say Derek Lowe is wrong because he's in the minority. Minorities are sometimes right. But since the parent comment was arguing on authority and my lack thereof, I point …

This frequently comes up as a critique of my article, but I don't claim to be disrupting the field as a smart outsider. Rather, I looked at the field and concluded that the experts…

My oh shit moment was probably deep Q learning in 2013 (I guess that's not gen AI), but GPT-3 was pretty remarkable too.

Yes, I can't find a 30%-slowdown number either. I'll add to this: the referenced trial occurred over 8 weeks, so even if we stipulate that the improvements in cognition (which are …

Little changed in 18 years: https://web.archive.org/web/20080511133831/https://www.vatic...